The PCSK9 Revolution in Cholesterol Reduction

Learning Objectives

Understand the safety and efficacy of ultra-low LDL cholesterol in the secondary prevention of cardiovascular events.
Discuss the evidence supporting PCSK9 inhibitors in the management of dyslipidemia.
Appreciate the clinical application of the recent Canadian lipid guidelines.
Understnd the genetic basis of hypercholesterolemia.
Understand the barriers of using injectible therapies in cardiovascular prevention.
Discuss ongoing clinical trials in PCSK9 inhibitors in cardiovascular protection.

Agenda

Click to See Video in Chapters

00:00:00

Opening Remarks
Dr. Lawrence A. Leiter (Chair)

00:03:42

The Latest Insights into the Biology of PCSK9
Dr. Nabil G. Seidah

00:28:48

Low vs Ultralow LDL: What is the Evidence to Support This?
Dr. Ruth McPherson

00:50:55

The 2015 Canadian Lipid Guidelines
Dr. Jean C. Grégoire

01:09:21

The Alirocumab Clinical Trials Program: What have we learned?
Dr. Shaun G. Goodman

01:33:50

The Evolocumab Clinical Trials Program: What have we learned?
Dr. Lawrence A Leiter

01:53:53

The Bococizumab Clinical Trials Program: What have we learned?
Dr. Paul M. Ridker

02:22:23

Homozygous and Heterozygous Familial Hypercholesterolemia: How have the PCSK9 inhibitors closed the gap in this population?
Dr. Robert A. Hegele

02:50:27

Real life use of PCSK9 inhibitors: Who is the right patient? Case based moderated discussion
Dr. Subodh Verma

03:04:44

Practical Aspects of Using Injectable Agents in Primary Care Practice
Dr. Shafiq Qaadri

Chair

Lawrence A. Leiter
MD, FRCPC, FACP, FACE, FAHA
Endocrinologist, St. Michael’s Hospital
Professor of Medicine and Nutritional Sciences, University of Toronto

Subodh Verma
MD, PhD, FRCSC, FAHA
Cardiac Surgeon, St. Michael’s Hospital
Professor of Surgery and Pharmacology & Toxicology, University of Toronto
Canada Research Chair in Atherosclerosis

Faculty

Nabil G. Seidah
CM, OQ, PhD, MSRC
Director, Biochemical Neuroendocrinology
Research Unit
Full IRCM Research Professor
Full Research Professor, Department of Medicine
(accreditation in molecular biology and biochemistry),
Université de Montréal
Adjunct Professor, Department of Medicine (Division of
Experimental Medicine), McGill University
Canada Research Chairholder in Precursor Proteolysis
2011 Wilder-Penfield Prix du Québec
Member, Order of Canada
Officer, Ordre national du Québec
Fellow, Royal Society of Canada

Ruth McPherson
BSc, MSc, PhD, MD, FRCPC
Director, Ruddy Canadian Cardiovascular
Genetics Centre
Director, Atherogenomics Laboratory and Lipid Clinic
Director of Research, Division of Cardiology
University of Ottawa Heart Institute
Professor, Departments of Medicine and Biochemistry
University of Ottawa

Jean C. Grégoire
MD, FRCPC, FACC, FACP
Associate Professor in Medicine,
Université de Montreal,
Interventional Cardiologist,
Institut de cardiologie de Montreal
Montreal, QC, Canada

Shaun G. Goodman
MD, MSc, FRCPC, FACC, FAHA, FESC
Associate Head and Staff Cardiologist,
Division of Cardiology, St. Michael’s Hospital
Professor and Heart & Stroke Foundation of Ontario
(Polo) Chair, University of Toronto
Consultant, Canadian Heart Research Centre
Adjunct Professor, University of Alberta,
Canadian VIGOUR Centre Faculty

Lawrence A. Leiter
MD, FRCPC, FACP, FACE, FAHA
Endocrinologist, St. Michael’s Hospital
Professor of Medicine and Nutritional Sciences, University of Toronto

Paul M. Ridker
MD, MPH, FACC, FAHA
Director, Cardiovascular Disease Prevention, Brigham and Women’s Hospital
Eugene Braunwald Professor of Medicine, Harvard Medical School
Robert A Hegele,
MD, FRCPC, FACP, FAHA, FCAHS
Jacob J. Wolfe Distinguished Medical Research Chair in Human Gene Function, Edith Schulich Vinet Canada Research Chair in Human Genetics
Martha Blackburn Chair in Cardiovascular Research, Distinguished University Professor of Medicine and Biochemistry, Unviersity of Western Ontario

Subodh Verma
MD, PhD, FRCSC, FAHA
Cardiac Surgeon, St. Michael’s Hospital
Professor of Surgery and Pharmacology & Toxicology, University of Toronto
Canada Research Chair in Atherosclerosis

Shafiq Qaadri
MD, MPP
Family Physician
CME Lecturer, Medical Writer